Understanding how KSHV virus affects cancer in people with weakened immune systems
KSHV Latency Regulation
This study is looking at how the Kaposi's sarcoma herpesvirus, which can cause cancer in people with weakened immune systems like those with AIDS, stays in infected cells and helps cancer cells survive, with the hope of finding new ways to treat these cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10975930 on NIH RePORTER |
What this research studies
This research investigates the Kaposi's sarcoma herpesvirus (KSHV), which is linked to several cancers, particularly in individuals with compromised immune systems, such as those with AIDS. The study focuses on how KSHV maintains its presence in infected cells and the role of specific viral proteins in promoting tumor cell survival. By examining the mechanisms of KSHV latency and its interaction with host cell processes, the research aims to uncover potential therapeutic targets for treating related malignancies. Patients may benefit from insights that could lead to new treatment strategies for KSHV-associated cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Kaposi's sarcoma, primary effusion lymphoma, or multicentric Castleman's disease, particularly those with a history of AIDS.
Not a fit: Patients without KSHV-related malignancies or those with intact immune systems may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for cancers associated with KSHV, improving outcomes for affected patients.
How similar studies have performed: Previous research has shown promising results in understanding KSHV latency and its role in cancer, indicating that this approach has potential for significant advancements.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Kaye, Kenneth M — Brigham and Women's Hospital
- Study coordinator: Kaye, Kenneth M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.