Understanding how KSHV causes Kaposi's Sarcoma cells to grow uncontrollably
Mechanisms of KSHV-induced endothelial cell loss of contact inhibition of proliferation
This project helps us understand how the Kaposi's Sarcoma virus (KSHV) makes cells grow too much, leading to cancer in people with weakened immune systems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11159572 on NIH RePORTER |
What this research studies
Kaposi's Sarcoma is a cancer caused by the KSHV virus, often seen in people with AIDS. Normally, healthy cells know when to stop growing when they touch other cells, a process called contact inhibition. However, in Kaposi's Sarcoma, the infected cells lose this control and keep multiplying. This research aims to discover exactly how KSHV disrupts this natural "stop growing" signal in cells, focusing on specific viral components and cell changes. By uncovering these basic steps, we hope to find new ways to stop the cancer from forming or growing.
Who could benefit from this research
Good fit: This foundational research is relevant to patients with Kaposi's Sarcoma or those at risk due to KSHV infection, especially individuals with AIDS.
Not a fit: Patients without Kaposi's Sarcoma or KSHV infection would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that prevent or slow the growth of Kaposi's Sarcoma by targeting how the virus makes cells multiply uncontrollably.
How similar studies have performed: While the exact mechanisms of KSHV's effect on cell growth control are not fully known, this work builds upon preliminary findings and general knowledge of viral oncogenesis.
Where this research is happening
Chicago, United States
- Northwestern University — Chicago, United States (Active)
Researchers
- Principal investigator: Gottwein, Eva Henriette — Northwestern University
- Study coordinator: Gottwein, Eva Henriette
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.