Understanding how Klebsiella bacteria adapt and survive in different environments
Official title: Control of Klebsiella capsule biosynthesis and attachment
Funded at University of Pittsburgh at Pittsburgh · NIH-11138270 · Data updated 2026-11-12
This study looks at how Klebsiella bacteria create a protective layer that helps them survive in different places, including our gut, and aims to understand how this layer helps them stick around and thrive in our bodies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $397,500 |
| NIH project number | 7R35GM150588-02 |
| Project ID | NIH-11138270 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with gastrointestinal conditions or those at risk of infections related to Klebsiella bacteria.
✕Less likely to help
Patients with conditions unrelated to bacterial infections or gastrointestinal health may not benefit from this research.
What this research studies
This research investigates how Klebsiella bacteria produce a protective outer layer called capsular polysaccharide (CPS) and how this affects their ability to survive and thrive in various environments, including the human gut. By examining the signals that influence CPS production and its attachment to the bacterial surface, the study aims to uncover the mechanisms that allow these bacteria to colonize and persist in the gastrointestinal tract. The research employs advanced techniques to analyze bacterial behavior and interactions at both the cellular and population levels, providing insights into their adaptability and resilience.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing infections caused by Klebsiella and improving gut health.
How similar studies have gone: Previous research has shown promising results in understanding bacterial adaptation mechanisms, indicating that this approach has potential for success.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Mike, Laura Anzaldi — University of Pittsburgh at Pittsburgh
- Study coordinator: Mike, Laura Anzaldi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.