Understanding how kinesin motors work in cells
Function and regulation of kinesin motors in cells
This study is looking at how a special type of motor protein called kinesin-2 helps move important materials inside cells and keeps everything running smoothly, especially in tiny hair-like structures called cilia that help cells sense their surroundings; understanding this could help us learn more about certain diseases that happen when these motors don’t work properly.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Knoxville NIH-funded |
| Lab location | 1 site (Knoxville, United States) |
| Project ID | NIH-10925214 on NIH RePORTER |
What this research studies
This research investigates the role of kinesin motors, specifically kinesin-2, in transporting cellular materials and their regulation within cells. It focuses on how these motors contribute to essential cellular processes, including the functioning of cilia, which are important for sensing environmental signals. By studying these mechanisms, the research aims to uncover how dysfunctions in kinesin motors can lead to diseases known as ciliopathies. The approach includes both in vitro studies and cellular assays to observe the behavior of these motors in live cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by ciliopathies or related disorders that impact cellular transport mechanisms.
Not a fit: Patients with conditions unrelated to ciliary function or intracellular transport may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the treatment of diseases caused by ciliary dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding the roles of kinesin motors in cellular processes, indicating that this area of study has potential for significant advancements.
Where this research is happening
Knoxville, United States
- University of Tennessee Knoxville — Knoxville, United States (Active)
Researchers
- Principal investigator: Engelke, Martin F. — University of Tennessee Knoxville
- Study coordinator: Engelke, Martin F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.