Understanding how kinesin motor proteins are inhibited
Mechanisms of kinesin motor protein inhibition
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10873887
This study is looking at how a special protein can stop kinesin motor proteins from doing their job in our cells, which is important for things like moving materials around and cell division, and it could help us find new ways to treat related health issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10873887 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which kinesin motor proteins, essential for cellular processes like transport and cell division, are regulated through inhibition. The team will explore how a specific protein, KIFBP, interacts with kinesin to block its function and how light chains influence this inhibition. By using advanced techniques such as site-specific mutagenesis and structural studies, the researchers aim to uncover the molecular details of these interactions. This knowledge could lead to new insights into cellular function and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve disruptions in cellular transport or division, such as neurodegenerative diseases.
Not a fit: Patients with conditions unrelated to cellular transport or kinesin function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases related to cellular transport and division.
How similar studies have performed: While the specific mechanisms of KIFBP-mediated kinesin inhibition are being explored, similar approaches in understanding motor protein regulation have shown promise in other studies.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CIANFROCCO, MICHAEL — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: CIANFROCCO, MICHAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.