Understanding how kinases work in cancer using tumor data
Official title: Inferring Kinase Activity from Tumor Phosphoproteomic Data
Funded at University of Virginia · NIH-10917357 · Data updated 2026-11-12
This study is testing a new way to look at how certain enzymes called kinases are working in tumor samples, which could help doctors choose the best treatments for cancer patients based on their unique tumor traits, all without needing extra tissue samples.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $369,343 |
| NIH project number | 5U01CA284193-02 |
| Project ID | NIH-10917357 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with solid tumors who may benefit from kinase inhibitor therapies.
✕Less likely to help
Patients with cancers that do not involve kinase dysregulation or those who are not candidates for kinase inhibitors may not benefit from this research.
What this research studies
This research focuses on a new method called KSTAR to analyze kinase activity in tumor biopsies by examining their phosphoproteomic profiles. Kinases are enzymes that play a crucial role in regulating cell functions, and their dysregulation can lead to cancer progression. By using KSTAR, researchers aim to improve the precision of kinase inhibitor therapies, helping to better match these treatments to patients based on their specific tumor characteristics. The approach does not require paired tissue samples, making it more versatile and robust than existing methods.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized cancer treatments for patients by improving the matching of therapies to individual tumor profiles.
How similar studies have gone: Other research has shown promise in using similar approaches to analyze kinase activity, indicating that this method could be a valuable advancement in cancer treatment.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Naegle, Kristen M — University of Virginia
- Study coordinator: Naegle, Kristen M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.