Understanding how kidney receptors affect high blood pressure
Renal AT2 Receptors in Hypertension
This study is looking at how certain receptors in the kidneys affect sodium levels and blood pressure, using special mice to help find new ways to treat high blood pressure that could benefit patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10794207 on NIH RePORTER |
What this research studies
This research investigates the role of angiotensin type-2 receptors (AT2Rs) in regulating sodium retention and blood pressure control in the kidneys. By using specially developed mice that lack these receptors, the study aims to uncover how AT2Rs influence sodium excretion and identify the signaling pathways involved. The research also seeks to explore potential therapeutic targets for hypertension, particularly focusing on the activation of specific proteins that could help manage high blood pressure. Patients may benefit from insights that could lead to new treatments for hypertension.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with hypertension, particularly those who may not respond well to current treatments.
Not a fit: Patients with secondary hypertension due to identifiable causes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing hypertension, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding the role of kidney receptors in blood pressure regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Keller, Susanna R — University of Virginia
- Study coordinator: Keller, Susanna R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.