Understanding how kidney proteins affect acid-base balance in health and disease
The Biology of NBCe1 in Health and Disease
This study is looking at how certain proteins in the kidneys help move important minerals, and how changes in these proteins can cause kidney problems like renal tubular acidosis in babies and kids, with the goal of finding better ways to diagnose and treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10609427 on NIH RePORTER |
What this research studies
This research investigates the role of specific proteins in the kidneys that are crucial for transporting ions like sodium and bicarbonate. It focuses on understanding how mutations in these proteins can lead to conditions such as renal tubular acidosis, particularly in infants and children. By using advanced imaging techniques and computational analyses, the researchers aim to uncover the molecular mechanisms behind these mutations and their impact on kidney function. This knowledge could lead to better diagnostic and therapeutic strategies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include infants and children diagnosed with renal tubular acidosis due to mutations in the NBCe1 or AE1 proteins.
Not a fit: Patients with renal tubular acidosis caused by factors unrelated to NBCe1 or AE1 mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could improve the understanding and treatment of renal tubular acidosis, potentially leading to better health outcomes for patients with this condition.
How similar studies have performed: Other research has shown success in understanding similar transport mechanisms in the kidneys, making this approach promising.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Kurtz, Ira — University of California Los Angeles
- Study coordinator: Kurtz, Ira
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.