Understanding how kidney injury leads to scarring and chronic disease
Epigenetic Regulation of Kidney Fibrosis following AKI
This study is looking at how certain proteins and tiny molecules in the kidneys help them heal after an injury, with the hope of finding better treatments for people who might develop long-term kidney problems after such injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10810713 on NIH RePORTER |
What this research studies
This research investigates the role of specific proteins and microRNAs in the healing process of the kidneys after acute injury. It focuses on how these factors can either promote recovery or lead to chronic kidney disease. By studying the behavior of certain cells in the kidney, the research aims to identify mechanisms that could be targeted for better treatment outcomes. Patients may benefit from insights that could lead to new therapies for kidney fibrosis following acute kidney injury.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have suffered from acute kidney injury and are at risk of developing chronic kidney disease.
Not a fit: Patients with chronic kidney disease not related to acute kidney injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent chronic kidney disease in patients who have experienced acute kidney injury.
How similar studies have performed: Other research has shown promising results in understanding the role of epigenetic factors in kidney disease, suggesting that this approach could lead to significant advancements.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Hyndman, Kelly — University of Alabama at Birmingham
- Study coordinator: Hyndman, Kelly
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.