Understanding how kidney injury affects heart function
Cardiac dysfunction after ischemic AKI in mice
This study is looking at how kidney injuries can lead to heart problems, especially by checking what happens to energy production in the heart after a kidney injury, and it’s aimed at helping people who have experienced kidney issues to improve their heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10824241 on NIH RePORTER |
What this research studies
This research investigates the connection between acute kidney injury (AKI) and heart dysfunction, known as cardiorenal syndrome type 3 (CRS3). The study focuses on identifying the mechanisms that lead to heart problems following kidney injury, particularly how energy production in the heart is affected. Researchers will analyze blood and heart tissue samples from mice to find out which metabolites are lacking after AKI and how these deficiencies impact heart health. By understanding these processes, the research aims to uncover potential targets for improving heart function in patients with kidney injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced acute kidney injury and are at risk for heart dysfunction.
Not a fit: Patients with chronic kidney disease or those without any history of kidney injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function in patients suffering from kidney injuries.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between kidney and heart health, but this specific approach is relatively novel.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Faubel, Sarah G — University of Colorado Denver
- Study coordinator: Faubel, Sarah G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.