Understanding how kidney function is affected by salt and diabetes
Official title: Novel Mechanisms Regulating Renal Perfusion and Kidney Redox Biology: Role in Salt Sensitive Hypertension
Funded at University of Arizona · NIH-11280843 · Data updated 2026-11-12
This study is looking at how type II diabetes and metabolic syndrome can cause high blood pressure when there's too much salt in the diet, focusing on a specific receptor in the body, and it hopes to find new ways to help people with diabetes manage their blood pressure better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | February 8, 2025 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $153,846 |
| NIH project number | 7K01DK126792-05 |
| Project ID | NIH-11280843 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type II diabetes or metabolic syndrome who experience hypertension.
✕Less likely to help
Patients without type II diabetes or metabolic syndrome, or those with other unrelated forms of hypertension, may not benefit from this research.
What this research studies
This research investigates the mechanisms by which type II diabetes and metabolic syndrome lead to salt-sensitive hypertension, focusing on a specific receptor called PPARγ. The study uses a mouse model with a genetic mutation that impairs this receptor to explore how it affects kidney blood flow and function, particularly under high salt conditions. By examining the relationship between PPARγ activity, oxidative stress, and renal blood flow, the research aims to uncover new insights into managing hypertension in patients with diabetes. Patients may benefit from findings that could lead to improved treatments for hypertension linked to diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing hypertension in patients with type II diabetes and metabolic syndrome.
How similar studies have gone: Previous research has shown that targeting PPARγ can effectively lower blood pressure in diabetic patients, suggesting a promising avenue for this study.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Wu, Jing O. — University of Arizona
- Study coordinator: Wu, Jing O.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.