Understanding how kidney function is affected by insulin resistance in diabetes
Elucidating the pathophysiology and molecular mechanisms of renal insulin resistance
['FUNDING_FELLOWSHIP'] · YALE UNIVERSITY · NIH-11041091
This study is looking at how the kidneys might affect insulin resistance in people with Type 2 diabetes, especially when they eat a high-fat diet, to help find better ways to manage diabetes.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11041091 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the kidneys in insulin resistance associated with Type 2 diabetes (T2D). It aims to uncover the molecular mechanisms that lead to impaired insulin signaling in the renal cortex, particularly in response to high-fat diets. By studying the accumulation of specific molecules and their effects on insulin receptors, the research seeks to clarify how kidney function contributes to overall glucose regulation in the body. This could provide insights into new treatment strategies for managing diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Type 2 diabetes, particularly those experiencing complications related to kidney function.
Not a fit: Patients without diabetes or those with other forms of kidney disease unrelated to insulin resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for Type 2 diabetes by targeting kidney-related insulin resistance.
How similar studies have performed: Previous research has indicated that understanding insulin resistance in the liver has led to significant advancements in diabetes treatment, suggesting potential for success in this novel area of kidney research.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUBBARD, BRANDON — YALE UNIVERSITY
- Study coordinator: HUBBARD, BRANDON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus