Understanding how kidney function changes affect heart failure outcomes
Official title: Relation between acute changes in kidney function with clinical outcomes among patients with heart failure
Funded at Tufts Medical Center · NIH-11012781 · Data updated 2026-11-12
This study is looking at how sudden changes in kidney function affect the health and recovery of people with heart failure, so we can better understand what helps them live longer and stay out of the hospital.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 1, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $190,929 |
| NIH project number | 5K23DK128657-03 |
| Project ID | NIH-11012781 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients admitted to the hospital with acute heart failure and existing kidney function issues.
✕Less likely to help
Patients with stable heart function and no history of kidney problems may not benefit from this research.
What this research studies
This research investigates the relationship between acute changes in kidney function and clinical outcomes in patients with heart failure. It aims to clarify how declines in kidney function, measured by estimated glomerular filtration rate (eGFR), relate to long-term kidney health, mortality, and hospitalizations due to heart failure. The study will involve analyzing data from patients admitted to Tufts Medical Center, using both retrospective and prospective methods to gather information on kidney function, heart congestion, and related biological markers. By identifying key risk factors, the research seeks to improve understanding of patient outcomes in heart failure.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies for patients with heart failure, potentially improving their kidney function and overall health outcomes.
How similar studies have gone: Previous research has shown varying results regarding the impact of kidney function on heart failure outcomes, indicating that this area is still under investigation and holds potential for new insights.
Where this research is happening
-
Tufts Medical Center
Boston, United States Active
Researchers
- Principal investigator: Mccallum, Wendy — Tufts Medical Center
- Study coordinator: Mccallum, Wendy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.