Understanding how kidney disease affects the immune response to fungal infections
Mechanisms of neutrophil dysfunction in antifungal immunity
This study is looking into why people with kidney disease are more likely to get serious fungal infections and is exploring how certain immune cells don’t work as well when kidney problems are present, with hopes of finding better ways to help those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10673766 on NIH RePORTER |
What this research studies
This research investigates why patients with kidney disease are more susceptible to severe fungal infections caused by Candida albicans. It focuses on the role of neutrophils, a type of immune cell, and how their function is impaired in the presence of uremic toxins that accumulate due to kidney dysfunction. By using a mouse model that mimics kidney disease, the researchers aim to uncover the mechanisms behind this immune deficiency, which could lead to better treatment strategies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with kidney disease who are at risk for disseminated candidiasis.
Not a fit: Patients without kidney disease or those not at risk for fungal infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients with kidney disease who are at risk of life-threatening fungal infections.
How similar studies have performed: Previous research has shown that understanding immune dysfunction in chronic conditions can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Nolin, Thomas Douglas — University of Pittsburgh at Pittsburgh
- Study coordinator: Nolin, Thomas Douglas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.