Understanding how kidney cells communicate in kidney diseases
Mechanisms mediating podocyte-parietal epithelial cell crosstalk in proliferative glomerulopathies
['FUNDING_R01'] · STATE UNIVERSITY NEW YORK STONY BROOK · NIH-10840946
This study is looking at how certain kidney cells work together and respond to damage, which could help us find new ways to treat kidney diseases like Rapidly Progressive Glomerulonephritis and Focal Segmental Glomerulosclerosis, ultimately benefiting patients with chronic kidney issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY NEW YORK STONY BROOK (nih funded) |
| Locations | 1 site (STONY BROOK, UNITED STATES) |
| Trial ID | NIH-10840946 on ClinicalTrials.gov |
What this research studies
This research investigates the interactions between podocytes and parietal epithelial cells in the kidneys, which are crucial for maintaining kidney function. It focuses on how these cells communicate and respond to injury in conditions like Rapidly Progressive Glomerulonephritis and certain types of Focal Segmental Glomerulosclerosis. By exploring the role of specific signaling pathways, particularly the STAT3 pathway and its regulation by KLF4, the research aims to uncover mechanisms that could lead to new treatment strategies for chronic kidney disease. Patients may benefit from insights gained into the cellular processes that contribute to kidney damage.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with chronic kidney diseases, particularly those with Rapidly Progressive Glomerulonephritis or specific variants of Focal Segmental Glomerulosclerosis.
Not a fit: Patients with acute kidney injuries or those without chronic kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for chronic kidney diseases, potentially improving kidney health and patient outcomes.
How similar studies have performed: While the specific mechanisms being studied are novel, previous research has shown that understanding cellular interactions in kidney diseases can lead to significant advancements in treatment.
Where this research is happening
STONY BROOK, UNITED STATES
- STATE UNIVERSITY NEW YORK STONY BROOK — STONY BROOK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MALLIPATTU, SANDEEP K — STATE UNIVERSITY NEW YORK STONY BROOK
- Study coordinator: MALLIPATTU, SANDEEP K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.