Understanding how kidney cell structures affect electrical signaling
Deciphering polycystin-dependent electric signaling of primary cilia in the renal system
['FUNDING_CAREER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10693400
This study is looking at how tiny structures in kidney cells, called primary cilia, work and how changes in certain proteins can cause kidney diseases like ADPKD, with the hope of finding new ways to treat these conditions.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10693400 on ClinicalTrials.gov |
What this research studies
This research investigates the role of primary cilia in kidney cells, particularly focusing on how mutations in specific proteins can disrupt their function and lead to diseases like Autosomal Dominant Polycystic Kidney Disease (ADPKD). By using advanced techniques to measure electrical activity in these cilia, the study aims to uncover the mechanisms behind ciliary signaling and how it is affected by genetic mutations. This could provide insights into the development of new treatments for kidney diseases linked to ciliary dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Autosomal Dominant Polycystic Kidney Disease or related ciliopathies.
Not a fit: Patients with kidney diseases not related to ciliary dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential therapies for patients suffering from kidney diseases caused by ciliary defects.
How similar studies have performed: Previous research has shown promising results in understanding ciliary function and its implications in kidney diseases, indicating that this approach has potential for success.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HA, KOTDAJI — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: HA, KOTDAJI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.