Understanding how kidney cell injury leads to cyst formation in ciliopathies
Official title: Injury Response Mediated Pathogenesis in Renal Ciliopathies
Funded at University of Alabama at Birmingham · NIH-10992598 · Data updated 2026-11-12
This study is looking at how tiny structures in kidney cells, called primary cilia, can cause fluid-filled cysts to form when they don’t work properly, especially in people with certain genetic conditions, and it aims to find new ways to help treat kidney diseases related to these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | February 1, 2023 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $477,069 |
| NIH project number | 5R01DK115752-07 |
| Project ID | NIH-10992598 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic predispositions to renal ciliopathies or those experiencing kidney dysfunction.
✕Less likely to help
Patients without any form of renal ciliopathy or those with unrelated kidney conditions may not benefit from this research.
What this research studies
This research investigates the role of primary cilia in kidney cells and how their dysfunction can lead to the formation of cysts, which are fluid-filled sacs. The study focuses on how renal injury affects these cells and promotes cyst development, particularly in individuals with specific genetic mutations. By using mouse models, researchers will analyze the cellular responses to injury and the mechanisms that drive cystogenesis, aiming to uncover the underlying processes that contribute to kidney disease. This research could provide insights into potential therapeutic targets for treating renal ciliopathies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce cyst formation in patients with kidney diseases related to ciliopathies.
How similar studies have gone: Previous studies have shown that understanding the role of cilia in kidney function can lead to significant advancements in treating related diseases, indicating a promising avenue for this research.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Yoder, Bradley K. — University of Alabama at Birmingham
- Study coordinator: Yoder, Bradley K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.