Understanding how kidney cell formation affects signaling pathways
Novel Role of Nephron Epithelialization in Nuclear Signaling
This study is looking at how certain cells in the kidneys develop and communicate, especially in kids with kidney problems from birth, to help us understand why these issues happen and find new ways to treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11089317 on NIH RePORTER |
What this research studies
This research investigates the role of nephron epithelialization in nuclear signaling, particularly focusing on congenital anomalies of the kidney and urinary tract (CAKUT), which are a leading cause of pediatric kidney disease. The study explores how disruptions in specific cellular pathways can lead to malformations in kidney tubules, which are essential for kidney function. By examining the mechanisms that promote cell junction formation among nephron progenitor cells, the research aims to uncover new insights into kidney development and potential therapeutic targets. Patients may benefit from a better understanding of the genetic and biological factors contributing to kidney anomalies.
Who could benefit from this research
Good fit: Ideal candidates for this research include infants and children diagnosed with congenital anomalies of the kidney and urinary tract.
Not a fit: Patients with kidney conditions unrelated to congenital anomalies or those with acquired kidney diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating congenital kidney defects in children.
How similar studies have performed: Previous studies have shown promising results in understanding kidney development through similar cellular signaling pathways, indicating that this research builds on established findings.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Miller, Rachel Katherine — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Miller, Rachel Katherine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.