Understanding How Kidney Cancer Spreads
ccRCC Metastatic Competency Determinants
This research looks at what causes clear cell kidney cancer to spread to other parts of the body, aiming to help identify patients at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11138630 on NIH RePORTER |
What this research studies
Many kidney cancer patients face the challenge of their cancer spreading, which is called metastasis. This project focuses on clear cell renal cell carcinoma (ccRCC) to understand why some tumors spread while others do not. Researchers are studying tumor samples from patients whose kidney cancer has grown into blood vessels, a sign that it might spread. By comparing the genetic makeup of tumors that spread versus those that didn't, they hope to find specific factors that predict metastasis. This knowledge could help doctors better manage the disease and identify patients who need more aggressive treatment.
Who could benefit from this research
Good fit: This research is relevant to patients diagnosed with clear cell renal cell carcinoma, especially those whose tumors have shown growth into blood vessels.
Not a fit: Patients with non-clear cell types of kidney cancer or those whose cancer has not shown signs of spreading into blood vessels may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could help doctors predict which kidney cancer patients are most likely to experience cancer spread, allowing for more personalized and effective treatment plans.
How similar studies have performed: While the specific determinants of metastatic competence in ccRCC are still being uncovered, previous research has shown that analyzing tumor characteristics can help predict cancer behavior.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Malladi, Srinivas — Ut Southwestern Medical Center
- Study coordinator: Malladi, Srinivas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.