Understanding how kidney blood vessels respond to acute kidney injury
Official title: Regulation of Lymphatic and Vascular Remodeling in Acute Kidney Injury
Funded at University of Alabama at Birmingham · NIH-10876933 · Data updated 2026-11-12
This study is looking at how kidney blood vessels react to sudden kidney injury and how growing lymphatic vessels might help heal the damage, with the hope of finding new treatments that could benefit patients with this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | July 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $42,629 |
| NIH project number | 5F30DK135349-02 |
| Project ID | NIH-10876933 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced acute kidney injury, particularly those hospitalized or critically ill.
✕Less likely to help
Patients with chronic kidney disease who are not currently experiencing acute kidney injury may not benefit from this research.
What this research studies
This research investigates the response of kidney blood vessels to acute kidney injury (AKI), a serious condition affecting many hospitalized patients. The study focuses on the role of lymphatic vessels in the kidneys and how their growth can help mitigate damage caused by AKI. By examining the mechanisms behind blood vessel changes during injury, the research aims to identify new therapeutic strategies to improve kidney health. Patients may benefit from insights that could lead to targeted treatments for AKI.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve kidney function and outcomes for patients suffering from acute kidney injury.
How similar studies have gone: Previous research has shown promise in understanding vascular responses in kidney injury, but this specific approach to studying lymphatic and blood vessel interactions in AKI is relatively novel.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Ghajar-Rahimi, Gelare — University of Alabama at Birmingham
- Study coordinator: Ghajar-Rahimi, Gelare
Related research
Other NIH-funded projects on the same topics.
-
SEAK Alliance: Improving Care for AKI Patients in the Southeast
A national, patient-centered effort to improve post-hospital care for people who had acute kidney injury in the Southeast.
-
AKI-related delirium after heart surgery
This grant funds research to understand why some people develop delirium after heart surgery when they also have acute kidney injury.
-
Better ways to identify types of sudden kidney injury in U.S. Veterans
Researchers are looking for genetic and health patterns that define different types of sudden severe kidney injury in Veterans to help guide future care.
-
Neuroimmune control of kidney injury using noninvasive ultrasound
A new approach uses targeted ultrasound to gently stimulate nerves and immune signals to help the kidney recover after injury.
-
Structure-based approach to prevent kidney injury from polymyxin use
Aims to block how polymyxin damages the kidney so it can be used more safely to treat hard-to-kill infections.
-
Using smart computer predictions to prevent kidney injury after heart surgery
A machine-learning approach uses routinely collected hospital data to predict who might develop acute kidney injury after heart surgery, so clinicians can act early.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.