Understanding how key proteins called PP2A family phosphatases work in the body
Regulatory Mechanisms of PP2A Family Phosphatases
This work aims to understand how important proteins called phosphatases are controlled in our cells, which could help us learn more about conditions like cancer and diabetes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11187009 on NIH RePORTER |
What this research studies
Our cells constantly adjust to their surroundings by turning proteins on and off, a process called phosphorylation. While we know a lot about how proteins are turned on, less is understood about how they are turned off by phosphatases. This project looks at how a specific group of phosphatases, the PP2A family, respond to signals from the environment. We believe these phosphatases are constantly being put together and taken apart, which helps them target specific proteins and influence important body functions. By uncovering these basic mechanisms, we hope to find new ways to approach diseases.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future studies building on this work may seek patients with conditions like cancer or diabetes.
Not a fit: Patients not interested in the fundamental molecular mechanisms of cell signaling, or those seeking immediate clinical interventions, may not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this basic understanding of cell regulation could lead to new targets for therapies in diseases like cancer and diabetes.
How similar studies have performed: While the specific mechanisms of PP2A family phosphatase regulation are still being uncovered, the broader field of protein phosphorylation research has led to many successful drug developments.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Kong, Mei — University of California-Irvine
- Study coordinator: Kong, Mei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.