Understanding how ketosis affects diabetes remission in obese African Americans
Mechanisms of ketosis and near-normoglycemia remission in obese African Americans with ketosis-prone diabetes
This study is looking at how certain treatments can help improve blood sugar control in obese African Americans with a type of diabetes that can lead to serious complications, and it aims to find out what helps some people feel better and stay healthy.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10676968 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind ketosis-prone diabetes mellitus (KPDM) in obese African Americans, particularly those who have experienced diabetic ketoacidosis (DKA). It aims to understand how intensive insulin treatment can lead to improvements in insulin secretion and sensitivity, allowing some patients to achieve near-normoglycemia remission. By utilizing high-resolution metabolomics and magnetic resonance imaging, the study will analyze metabolic pathways and imaging characteristics to uncover factors that contribute to sustained remission. The research will build on previously collected samples and data to provide insights into this complex condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are obese African American individuals diagnosed with ketosis-prone diabetes mellitus who have experienced diabetic ketoacidosis.
Not a fit: Patients with type 1 diabetes or those who do not identify as obese African Americans may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for diabetes, particularly for those with ketosis-prone diabetes, enhancing patient outcomes and quality of life.
How similar studies have performed: While the specific mechanisms of ketosis in this population are not extensively studied, similar approaches in metabolic research have shown promise in understanding diabetes management.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Vellanki, Priyathama — Emory University
- Study coordinator: Vellanki, Priyathama
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.