Understanding how keratin proteins sense physical forces in cells
Molecular basis of force-sensing by the keratin network
This study is looking at how certain proteins in skin and other surface cells react when they experience physical pressure, which could help us understand how these cells move and work together, especially for people interested in skin health or healing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10992785 on NIH RePORTER |
What this research studies
This research investigates the role of keratin proteins in epithelial cells and how they respond to physical forces. By examining the interactions between keratin and other proteins when cells are subjected to mechanical stimulation, the study aims to uncover the mechanisms behind cell behavior and migration. The approach involves advanced biophysical techniques to label and identify proteins that interact with keratin under force, providing insights into how cells communicate and function in their environment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with epithelial tissue-related conditions, particularly those at risk for cancer metastasis.
Not a fit: Patients with non-epithelial tissue conditions or those not affected by cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating conditions related to cancer metastasis and tissue integrity.
How similar studies have performed: Previous research has shown promising results in understanding cellular responses to mechanical forces, indicating that this approach could yield valuable insights.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Yamada, Soichiro — University of California at Davis
- Study coordinator: Yamada, Soichiro
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.