Understanding how keratin proteins affect skin cell development.
Role of keratin intermediate filaments in skin epithelial differentiation.
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11088902
This study is looking at how certain proteins in your skin, called keratins, work and how changes in their genes can lead to skin problems, helping us understand how skin cells grow and react to stress.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11088902 on ClinicalTrials.gov |
What this research studies
This research investigates the role of keratin proteins in the differentiation of skin epithelial cells, focusing on how genetic mutations can lead to skin disorders. By examining the structure and function of keratin intermediate filaments, the study aims to uncover how these proteins contribute to the mechanical properties of skin cells and their ability to respond to stress. The research employs advanced molecular biology techniques to analyze keratin gene regulation and its impact on cell behavior, particularly in relation to signaling pathways that influence cell growth and differentiation.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetically determined skin epithelial disorders, particularly those related to keratin mutations.
Not a fit: Patients without skin disorders or those whose conditions are unrelated to keratin proteins may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for various skin disorders caused by keratin mutations.
How similar studies have performed: Previous research has shown promising results in understanding the role of keratin proteins in skin health, indicating that this approach has potential for significant advancements.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COULOMBE, PIERRE — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: COULOMBE, PIERRE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.