Understanding how keloids form and grow
Official title: Causative mechanisms for keloid formation
Funded at University of Connecticut Sch of Med/dnt · NIH-11002692 · Data updated 2026-11-12
This study is looking at how our genes might make some people more likely to develop keloids, which are those raised scars that can be uncomfortable, especially in individuals of African ancestry, to help find better ways to treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | January 1, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $421,796 |
| NIH project number | 5R01AR082440-02 |
| Project ID | NIH-11002692 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of keloid formation, particularly those of African descent.
✕Less likely to help
Patients without a history of keloids or those from populations not significantly affected by keloids may not benefit from this research.
What this research studies
This research investigates the genetic factors that contribute to the formation of keloids, which are raised scars that can be painful and itchy. By studying skin cells and using advanced techniques, the researchers aim to identify specific gene mutations that make some individuals more susceptible to developing keloids. The project focuses particularly on individuals of African ancestry, as they are disproportionately affected by this condition. The findings could lead to better understanding and potential new treatments for keloids.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for keloids, reducing their occurrence and severity in affected patients.
How similar studies have gone: Previous research has identified genetic variants associated with keloid formation, suggesting that this approach has potential for success.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Reichenberger, Ernst J — University of Connecticut Sch of Med/dnt
- Study coordinator: Reichenberger, Ernst J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.