Understanding how KCTD proteins affect brain signaling related to movement disorders
Official title: Role of KCTD proteins in striatal signaling
Funded at Augusta University · NIH-10872208 · Data updated 2026-11-12
This study is looking at how certain proteins in the brain affect movement control, which could help us understand and improve treatments for movement disorders like Parkinson's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $373,450 |
| NIH project number | 5R01NS129554-02 |
| Project ID | NIH-10872208 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing movement disorders such as Parkinson's disease or other related conditions.
✕Less likely to help
Patients with movement disorders not related to striatal signaling may not benefit from this research.
What this research studies
This research investigates the role of KCTD proteins in the signaling pathways of striatal neurons, which are crucial for movement control. By using advanced techniques like CRISPR and biochemical assays, the study aims to uncover how these proteins influence cAMP signaling and zinc transport in the brain. The findings could lead to a better understanding of movement disorders, potentially paving the way for new therapeutic strategies. Patients may benefit from insights that could improve treatment options for conditions like Parkinson's disease and other movement-related disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating movement disorders.
How similar studies have gone: While the specific focus on KCTD proteins is novel, similar research has shown promise in understanding signaling pathways in movement disorders.
Where this research is happening
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Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Muntean, Brian S — Augusta University
- Study coordinator: Muntean, Brian S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.