Understanding how KCNN1 affects heart rhythm problems
Official title: Defining the role of KCNN1 in atrial arrhythmias
Funded at Ohio State University · NIH-10666164 · Data updated 2026-11-12
This study is looking at a protein called KCNN1 to see how it affects atrial fibrillation, a common heart rhythm problem, and hopes to find new ways to treat it by focusing on this protein.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $157,500 |
| NIH project number | 1R03TR004471-01 |
| Project ID | NIH-10666164 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with atrial fibrillation or those at high risk for developing this condition.
✕Less likely to help
Patients without atrial fibrillation or those with other unrelated heart conditions may not benefit from this research.
What this research studies
This research investigates the role of a specific protein, KCNN1, in atrial fibrillation (AF), a common heart rhythm disorder. The study aims to identify how this protein contributes to the development of AF and whether targeting it could lead to new treatment options. By examining the expression of KCNN1 in heart cells, researchers hope to uncover its potential as a specific target for anti-arrhythmic therapies. This could lead to improved management of AF, which currently has limited treatment options.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that specifically target atrial fibrillation, improving patient outcomes and quality of life.
How similar studies have gone: Previous research has shown promise in targeting specific proteins for arrhythmia treatment, suggesting that this approach could be effective.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Terentyev, Dmitry a — Ohio State University
- Study coordinator: Terentyev, Dmitry a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.