Understanding how KBTBD2 affects bone development and growth disorders
Official title: The Role of KBTBD2 in Bone Development and SHORT Syndrome
Funded at Ut Southwestern Medical Center · NIH-11036225 · Data updated 2026-11-12
This study is looking at a gene called KBTBD2 to understand how it affects bone growth and could help kids with growth problems, using mice to learn more about how changes in this gene might lead to issues like slow growth and metabolism.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 19, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $451,000 |
| NIH project number | 1R21HD117154-01 |
| Project ID | NIH-11036225 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children experiencing growth disorders or related metabolic issues.
✕Less likely to help
Patients with growth disorders not linked to genetic factors or those outside the targeted age range may not benefit from this research.
What this research studies
This research investigates the role of a specific gene, KBTBD2, in bone development and its connection to childhood growth disorders. By using advanced genetic techniques in mice, the researchers aim to uncover how mutations in this gene lead to issues like growth retardation and metabolic problems. The study involves examining how KBTBD2 influences bone cell development and insulin signaling, which could provide insights into potential treatments for affected children. The findings may help translate these molecular insights into therapeutic strategies for growth disorders.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for children with growth disorders, improving their overall health and development.
How similar studies have gone: Previous research has shown promising results in understanding genetic factors in growth disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Zhang, Zhao — Ut Southwestern Medical Center
- Study coordinator: Zhang, Zhao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.