Understanding how Kaposi's sarcoma herpesvirus spreads and how to stop it
Models for KHSV transmission and its inhibition
This study is looking at how Kaposi's sarcoma herpesvirus spreads, especially in young children with HIV, and it aims to find out if saliva plays a role in this process and if the body can create antibodies to help stop the virus from spreading.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Health Sciences Center NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-10876890 on NIH RePORTER |
What this research studies
This research investigates the transmission of Kaposi's sarcoma herpesvirus (KSHV), which is linked to a common cancer in sub-Saharan Africa, particularly among individuals with HIV. The team is studying how KSHV is acquired, focusing on early childhood transmission and the role of saliva. They are also exploring the immune response to KSHV, specifically the production of neutralizing antibodies, to determine if these antibodies can prevent the virus from spreading. By understanding these mechanisms, the research aims to develop strategies to inhibit KSHV transmission and improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living in sub-Saharan Africa, particularly those at risk for Kaposi's sarcoma or HIV-infected individuals.
Not a fit: Patients who are not at risk for KSHV or Kaposi's sarcoma, or those living outside of the endemic regions, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new methods for preventing the transmission of KSHV and reducing the incidence of Kaposi's sarcoma.
How similar studies have performed: Previous research has shown success in understanding HIV transmission and immune responses, suggesting that similar approaches may yield valuable insights for KSHV.
Where this research is happening
New Orleans, United States
- Lsu Health Sciences Center — New Orleans, United States (Active)
Researchers
- Principal investigator: Wood, Charles — Lsu Health Sciences Center
- Study coordinator: Wood, Charles
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.