Understanding how jumping genes affect cell processes
DNA transposons and alternative pre-mRNA splicing.
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA BERKELEY · NIH-11085986
This research explores how "jumping genes" in our DNA might influence how our cells make proteins, which could be important for conditions like ALS and cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA BERKELEY (nih funded) |
| Locations | 1 site (BERKELEY, UNITED STATES) |
| Trial ID | NIH-11085986 on ClinicalTrials.gov |
What this research studies
Our bodies contain "jumping genes" called transposons that can move around within our DNA. This project looks at how these jumping genes, particularly a human gene called THAP9, might affect how our cells read genetic instructions to create proteins. Changes in this process, called alternative pre-mRNA splicing, are linked to diseases like ALS and certain cancers. By understanding these basic mechanisms, we hope to uncover new insights into these complex conditions.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future studies building on this work might seek individuals with ALS or certain cancers.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could reveal fundamental ways that genetic elements contribute to diseases like ALS and cancer, potentially leading to new targets for future treatments.
How similar studies have performed: This project builds on previous work identifying and characterizing transposons and their role in gene regulation, but its specific focus on human THAP9 in embryonic stem cells and its link to disease mechanisms represents a novel direction.
Where this research is happening
BERKELEY, UNITED STATES
- UNIVERSITY OF CALIFORNIA BERKELEY — BERKELEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RIO, DONALD C — UNIVERSITY OF CALIFORNIA BERKELEY
- Study coordinator: RIO, DONALD C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Amyotrophic Lateral Sclerosis Motor Neuron Disease, Cancers