Understanding how joint damage progresses after ACL injuries
Official title: Genomic and Imaging Markers to Understand and Predict Progression of Joint Damage After Injury
Funded at New York University School of Medicine · NIH-10899433 · Data updated 2026-11-12
This study is looking at how certain markers in your body can help predict how your knee might change after an ACL injury, and it's for people aged 18 to 40 who want to understand their recovery better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 8, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $706,587 |
| NIH project number | 5R01AR082225-02 |
| Project ID | NIH-10899433 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are physically active individuals aged 18 to 40 who have recently suffered an ACL injury.
✕Less likely to help
Patients who have not experienced an ACL injury or those over the age of 40 may not benefit from this research.
What this research studies
This research investigates the biological and imaging markers that can help predict the progression of joint damage following an anterior cruciate ligament (ACL) injury. By analyzing synovial fluid and extracellular vesicles from patients aged 18 to 40, the study aims to identify how the body's response to the injury can indicate future joint degradation. The approach includes measuring soluble biomarkers and utilizing advanced imaging techniques to assess changes over time. This comprehensive assessment could lead to better predictions of post-injury outcomes.
Why it matters
Potential benefit: If successful, this research could provide insights that help prevent or mitigate posttraumatic osteoarthritis in patients with ACL injuries.
How similar studies have gone: Previous research has shown promise in using biological markers to predict joint damage, but this specific approach is relatively novel.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Kirsch, Thorsten — New York University School of Medicine
- Study coordinator: Kirsch, Thorsten
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.