Understanding how JMJD4 affects pancreatic cancer
Official title: Role of JMJD4 in Pancreatic Cancer
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-10952842 · Data updated 2026-11-12
This study is looking at how a specific enzyme called JMJD4 affects the growth and spread of pancreatic cancer cells, with the hope of finding new ways to improve treatment options for patients battling this tough disease.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | July 17, 2024 |
| Project end | July 16, 2026 |
| Funding year | 2024 |
| Award (this year) | $145,000 |
| NIH project number | 1R03CA292973-01 |
| Project ID | NIH-10952842 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pancreatic cancer.
✕Less likely to help
Patients with other types of cancer or those without a pancreatic cancer diagnosis may not benefit from this research.
What this research studies
This research investigates the role of the enzyme JMJD4 in pancreatic cancer, a disease known for its low survival rates. The study aims to understand how JMJD4 influences cancer cell growth and invasion, as well as its interactions with key transcription factors involved in tumor development and resistance to treatment. By examining these mechanisms, the research seeks to uncover new therapeutic targets that could lead to better treatment options for patients. The approach includes both cellular experiments and molecular analysis to elucidate JMJD4's functions in pancreatic cancer.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve survival rates for pancreatic cancer patients.
How similar studies have gone: Previous research has shown promising results in targeting similar molecular pathways in cancer treatment, suggesting potential for success in this approach.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Janknecht, Ralf — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Janknecht, Ralf
Related research
Other NIH-funded projects on the same topics.
-
Microbial Dysbiosis and Its Role in Pancreatic Cancer
A doctor-researcher team at Northwestern University is studying how gut bacteria influence pancreatic cancer and its response to immunotherapy to find new ways to help patients.
-
Targeting aberrant enhancer landscapes in pancreatic cancer
A patient-facing look at a project that aims to understand how pancreatic cancer changes its cell identity and what that means for treatment.
-
Exosome-based microRNA biomarkers for early, non-invasive detection of pancreatic cancer
A study to develop a blood test that uses tiny RNA signals in exosomes to detect pancreatic cancer early, aiming to help people at risk or with early disease.
-
Exosome-based microRNA biomarkers for early detection of pancreatic cancer
A patient-friendly look at a study using tiny blood-based RNA markers inside exosomes to catch pancreatic cancer early without invasive procedures.
-
Programmable implanted living materials to fight pancreatic cancer
A patient-facing program will explore a safe, implantable living material that delivers sequential immunotherapies directly to pancreatic tumors to help fight cancer.
-
Targeting how platelets and pancreatic cancer talk to each other
A study exploring whether blocking the interaction between platelets and pancreatic cancer cells could slow cancer growth and spread and help identify new biomarkers.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.