Understanding how JC polyomavirus infects cells and causes disease
Characterization of Viral Receptors and Signaling Networks in JC Polyomavirus Infection
['FUNDING_R15'] · UNIVERSITY OF MAINE ORONO · NIH-10437461
This study is looking at how a virus called JC polyomavirus enters cells and causes a serious brain condition called PML, especially in people with weakened immune systems, like those with HIV or on certain MS treatments, to help find better ways to treat the disease.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MAINE ORONO (nih funded) |
| Locations | 1 site (ORONO, UNITED STATES) |
| Trial ID | NIH-10437461 on ClinicalTrials.gov |
What this research studies
This research investigates how the JC polyomavirus (JCPyV) interacts with specific receptors on host cells, leading to infection and the development of progressive multifocal leukoencephalopathy (PML). The study focuses on immunocompromised individuals, such as those with HIV or those receiving certain therapies for multiple sclerosis, who are at higher risk for PML. By exploring the mechanisms of JCPyV entry into cells, the research aims to uncover critical insights that could inform future treatment strategies. The approach includes detailed biological assays to characterize virus-receptor interactions and their implications for disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include immunocompromised individuals, particularly those living with HIV or undergoing immunomodulatory therapies.
Not a fit: Patients with robust immune systems who are not at risk for JCPyV infection or PML may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of PML and potentially identify new therapeutic targets for treatment.
How similar studies have performed: While the mechanisms of JCPyV infection are not fully understood, similar research approaches have successfully elucidated virus-host interactions in other viral infections.
Where this research is happening
ORONO, UNITED STATES
- UNIVERSITY OF MAINE ORONO — ORONO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MAGINNIS, MELISSA — UNIVERSITY OF MAINE ORONO
- Study coordinator: MAGINNIS, MELISSA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immunodeficiency Syndrome, Acquired Immune Deficiency Syndrome, Acquired Immuno-Deficiency Syndrome, Acquired Immunologic Deficiency Syndrome