Understanding how jawbone responds to growth factors and mechanical forces
Official title: Jawbone is unique: differential responses to growth factor signaling and mechanical loading
Funded at University of Michigan at Ann Arbor · NIH-10788667 · Data updated 2026-11-12
This study is looking at how the jawbone stays healthy and grows, especially how it reacts to certain signals and pressure, which could help improve dental treatments and bone grafting for patients with jawbone issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $429,000 |
| NIH project number | 1R21DE033500-01 |
| Project ID | NIH-10788667 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with jawbone defects, those requiring dental implants, or patients with conditions affecting jawbone health.
✕Less likely to help
Patients with no jawbone issues or those not requiring dental interventions may not benefit from this research.
What this research studies
This research investigates the unique characteristics of jawbone health, focusing on how it responds to growth factors and mechanical loading. By examining the behavior of osteoblasts, the cells responsible for bone formation, in the jaw compared to long bones, the study aims to uncover specific mechanisms that influence bone health. The research utilizes advanced techniques to analyze cellular responses and signaling pathways, which could lead to improved treatments for conditions affecting the jawbone. Patients may benefit from insights that enhance dental procedures and bone grafting techniques.
Why it matters
Potential benefit: If successful, this research could lead to better treatments for jawbone-related conditions, improving dental health and overall quality of life for patients.
How similar studies have gone: Previous research has shown success in understanding bone responses to growth factors, but this specific focus on jawbone mechanisms is relatively novel.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Mishina, Yuji — University of Michigan at Ann Arbor
- Study coordinator: Mishina, Yuji
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.