Understanding how itch signals are processed in the body
Mechanisms of Endosomal Signaling of Itch
This study is looking into how itch signals travel in the body and how certain receptors might help us find better treatments for people dealing with chronic itch.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10994160 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind how itch sensations are transmitted in the body, focusing on specific receptors involved in this process. It aims to explore how these receptors can signal from inside cells, particularly in endosomes, which could lead to new ways to treat chronic itch. By using advanced techniques, the study will examine the role of certain receptors in spinal cord signaling and how blocking their endosomal signaling might reduce itch-related behaviors in animal models. The findings could provide insights into developing more effective treatments for patients suffering from chronic itch.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic itch conditions, such as those related to skin disorders or neuropathic pain.
Not a fit: Patients with acute itch due to temporary irritants or those without chronic itch conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing chronic itch, improving the quality of life for affected patients.
How similar studies have performed: While the specific approach of targeting endosomal signaling in itch is relatively novel, similar research has shown promise in understanding receptor signaling pathways in other conditions.
Where this research is happening
New York, United States
- New York University — New York, United States (Active)
Researchers
- Principal investigator: Jensen, Dane D — New York University
- Study coordinator: Jensen, Dane D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.