Understanding how isocyanates cause asthma in workers
Deciphering Occupational Asthma Pathogenesis Caused by Isocyanate
This study is looking at how certain chemicals called isocyanates, which are found in many workplaces, can cause asthma in workers, and it hopes to find ways to better monitor and treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10942178 on NIH RePORTER |
What this research studies
This research investigates how exposure to isocyanates, chemicals used in various industries, leads to occupational asthma. By using a novel mouse model, the study aims to uncover the immune responses triggered by these chemicals and identify biomarkers that can help in monitoring exposure. The findings could improve disease screening, prevention, and treatment strategies for affected workers. The research addresses significant gaps in knowledge about diisocyanate asthma compared to environmental asthma.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been exposed to isocyanates in their workplace and are experiencing respiratory symptoms.
Not a fit: Patients who do not have a history of exposure to isocyanates or do not exhibit asthma symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment options for workers suffering from asthma caused by isocyanate exposure.
How similar studies have performed: Previous research has shown promise in understanding asthma mechanisms through animal models, indicating potential for success in this novel approach.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Wisnewski, Adam — Yale University
- Study coordinator: Wisnewski, Adam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.