Understanding how isocyanates cause asthma in workers
Official title: Deciphering Occupational Asthma Pathogenesis Caused by Isocyanate
Funded at Yale University · NIH-10942178 · Data updated 2026-11-12
This study is looking at how certain chemicals called isocyanates, which are found in many workplaces, can cause asthma in workers, and it hopes to find ways to better monitor and treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $652,908 |
| NIH project number | 1R01OH012726-01 |
| Project ID | NIH-10942178 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been exposed to isocyanates in their workplace and are experiencing respiratory symptoms.
✕Less likely to help
Patients who do not have a history of exposure to isocyanates or do not exhibit asthma symptoms may not benefit from this research.
What this research studies
This research investigates how exposure to isocyanates, chemicals used in various industries, leads to occupational asthma. By using a novel mouse model, the study aims to uncover the immune responses triggered by these chemicals and identify biomarkers that can help in monitoring exposure. The findings could improve disease screening, prevention, and treatment strategies for affected workers. The research addresses significant gaps in knowledge about diisocyanate asthma compared to environmental asthma.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment options for workers suffering from asthma caused by isocyanate exposure.
How similar studies have gone: Previous research has shown promise in understanding asthma mechanisms through animal models, indicating potential for success in this novel approach.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Wisnewski, Adam — Yale University
- Study coordinator: Wisnewski, Adam
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.