Understanding how iron-sulfur enzymes work
Official title: Chemical Approaches to Understanding the Mechanisms of Iron-Sulfur Enzymes
Funded at Massachusetts Institute of Technology · NIH-11018829 · Data updated 2026-11-12
This study is exploring how certain enzymes that contain iron and sulfur work in our bodies, with the goal of creating better treatments for diseases by understanding their structure and reactions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $647,301 |
| NIH project number | 1R35GM156872-01 |
| Project ID | NIH-11018829 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to enzyme dysfunction or diseases where iron-sulfur enzymes play a significant role.
✕Less likely to help
Patients with conditions unrelated to iron-sulfur enzymes or those not affected by enzyme dysfunction may not benefit from this research.
What this research studies
This research investigates the mechanisms of iron-sulfur enzymes, which play crucial roles in various biological processes related to human health and disease. By synthesizing models that mimic these enzymes, the project aims to characterize their structures and reactions at a molecular level. The researchers will use advanced spectroscopic techniques to gather detailed information about these enzymes and their intermediates, which could lead to the development of targeted inhibitors for diseases. Overall, the project combines chemistry and biology to enhance our understanding of these important enzymes.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for diseases by targeting iron-sulfur enzymes.
How similar studies have gone: Previous research has shown promise in understanding enzyme mechanisms through similar synthetic modeling approaches, indicating potential for success in this area.
Where this research is happening
-
Massachusetts Institute of Technology
Cambridge, United States Active
Researchers
- Principal investigator: Suess, Daniel Leif Migdow — Massachusetts Institute of Technology
- Study coordinator: Suess, Daniel Leif Migdow
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.