Understanding how iron metabolism differs between sexes in glioblastoma
Project 2: Sexual Dimorphism of Iron Metabolism in GBM
This study is looking at how iron levels in the body might affect brain cancer (glioblastoma) differently in men and women, with the goal of finding better treatment options for each sex, and patients may help by providing samples for the research.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10881798 on NIH RePORTER |
What this research studies
This research investigates the differences in iron metabolism between male and female patients with glioblastoma (GBM), a type of brain cancer. It aims to uncover the underlying mechanisms that contribute to the observed disparities in incidence and survival rates based on sex. By examining how iron levels and their bioavailability affect tumor growth and immune response, the study seeks to identify potential therapeutic strategies tailored to each sex. Patients may be involved in providing biological samples to help elucidate these differences.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with glioblastoma, particularly those interested in understanding how sex differences may affect their treatment options.
Not a fit: Patients with glioblastoma who do not identify as male or female, or those with other types of brain tumors, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, sex-specific treatments for glioblastoma patients.
How similar studies have performed: While there is ongoing research into sex differences in cancer, this specific focus on iron metabolism in glioblastoma is relatively novel and has not been extensively tested.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Connor, James Robert — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Connor, James Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.