Understanding how iron levels affect immune cell behavior in chronic kidney disease
Official title: Iron homeostasis and monocyte differentiation in patients with chronic kidney disease
Funded at Weill Medical Coll of Cornell Univ · NIH-10792914 · Data updated 2026-11-12
This study is looking at how iron levels in your immune cells might affect kidney health in people with chronic kidney disease, and it hopes to find new ways to help slow down kidney damage and related issues like anemia.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $122,040 |
| NIH project number | 5R03DK135897-02 |
| Project ID | NIH-10792914 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic kidney disease, particularly those experiencing anemia or related complications.
✕Less likely to help
Patients without chronic kidney disease or those who do not have issues related to iron metabolism may not benefit from this research.
What this research studies
This research investigates the role of iron homeostasis in the differentiation of immune cells, specifically monocytes, in patients with chronic kidney disease (CKD). It aims to understand how low levels of iron within these cells may contribute to kidney damage and complications such as anemia. By examining the behavior of circulating monocytes and their transformation into kidney macrophages, the study seeks to identify potential therapeutic targets to slow the progression of kidney fibrosis. Patients may be involved in assessments that explore their iron levels and immune cell function.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve kidney health and reduce complications for patients with chronic kidney disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of iron in immune cell function, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Akchurin, Oleh — Weill Medical Coll of Cornell Univ
- Study coordinator: Akchurin, Oleh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.