Understanding how iron enzymes activate oxygen in biological processes
Spectroscopic Characterization of Oxygen Intermediates in Non-heme and Heme Iron Enzymes
This study is looking at how certain enzymes that contain iron help activate oxygen, which could lead to better understanding of how antibiotics work and how they interact with other medications, ultimately helping patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11125758 on NIH RePORTER |
What this research studies
This research investigates the role of iron enzymes in activating oxygen, focusing on different classes of these enzymes based on their active site structures. By employing advanced spectroscopic methods, the study aims to analyze the geometric and electronic structures of oxygen intermediates formed during enzyme reactions. This could provide insights into how these enzymes function and their potential applications in drug metabolism and bioremediation. Patients may benefit from improved understanding of antibiotic agents and drug interactions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with conditions related to drug metabolism or those affected by antibiotic resistance.
Not a fit: Patients with conditions unrelated to enzyme function or drug metabolism may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to advancements in drug development and improved therapeutic strategies for various diseases.
How similar studies have performed: Other research has shown success in understanding enzyme mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Solomon, Edward I — Stanford University
- Study coordinator: Solomon, Edward I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.