Understanding how iron dynamics affect radiation resistance in esophageal cancer
Administrative Supplement: Investigating the role of iron redox dynamics in radiation resistance in esophageal cancer
['FUNDING_OTHER'] · UNIVERSITY OF TX MD ANDERSON CAN CTR · NIH-11072873
This study is looking into why some esophageal cancer patients don't respond well to radiation therapy and is exploring a special type of cell death related to iron levels, with the goal of finding better treatments for those who might struggle with radiation.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TX MD ANDERSON CAN CTR (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11072873 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind radiation resistance in esophageal cancer, particularly focusing on a process called ferroptosis, which is a type of cell death influenced by iron levels. The study aims to identify patients who are most at risk of developing resistance to radiation therapy and to explore new treatments that could help overcome this resistance. By analyzing both laboratory models and patient samples, the research seeks to bridge basic science with clinical applications, potentially leading to improved outcomes for patients undergoing radiation therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with locally advanced esophageal cancer who are undergoing radiation therapy.
Not a fit: Patients with early-stage esophageal cancer or those not receiving radiation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for esophageal cancer patients, reducing the likelihood of cancer recurrence after radiation therapy.
How similar studies have performed: Previous research has shown promise in understanding ferroptosis and its role in cancer treatment, suggesting that this approach could yield valuable insights.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TX MD ANDERSON CAN CTR — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GAN, BOYI — UNIVERSITY OF TX MD ANDERSON CAN CTR
- Study coordinator: GAN, BOYI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Center, Cancer Patient, Cancer Treatment, Cancer cell line, Cancers