Understanding how iron balance affects inflammatory bowel disease
The role of local iron homeostasis in inflammatory bowel disease
This study is looking at how iron levels affect kids with Crohn's disease and their anemia, hoping to find new ways to help them feel better and heal by understanding a hormone called hepcidin that controls iron in the body.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10896458 on NIH RePORTER |
What this research studies
This research investigates the role of iron homeostasis in patients with inflammatory bowel disease (IBD), particularly focusing on how dysregulated iron levels contribute to anemia, a common complication of IBD. The study aims to explore the hormone hepcidin, which regulates iron release in the body, and its impact on tissue healing in pediatric patients with Crohn's disease. By examining the relationship between hepcidin, iron availability, and inflammation, the research seeks to identify new therapeutic strategies for managing IBD and associated anemia. Patients may be involved in understanding how their iron levels affect their condition and treatment responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are pediatric patients diagnosed with Crohn's disease who are experiencing anemia.
Not a fit: Patients without inflammatory bowel disease or those not experiencing anemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve the management of anemia in patients with inflammatory bowel disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of iron homeostasis in other inflammatory conditions, suggesting potential for success in this area as well.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Bessman, Nicholas J. — Rutgers Biomedical and Health Sciences
- Study coordinator: Bessman, Nicholas J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.