Understanding how iron and copper are managed in cells
Iron Trafficking and Regulation in Biological Systems
['FUNDING_OTHER'] · TEXAS A&M UNIVERSITY · NIH-11016924
This study is looking at how our cells manage important metals like iron and copper to keep them healthy, using yeast cells to figure out how these metals are moved around and used, which could help us understand diseases caused by metal imbalances.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEXAS A&M UNIVERSITY (nih funded) |
| Locations | 1 site (COLLEGE STATION, UNITED STATES) |
| Trial ID | NIH-11016924 on ClinicalTrials.gov |
What this research studies
This research investigates the complex processes of iron and copper trafficking within cells, focusing on how these essential metals are regulated to prevent cellular damage. The team employs advanced techniques, including custom liquid chromatography and mass spectrometry, to analyze how iron is distributed to various proteins in yeast cells. By developing mathematical models, they aim to uncover the mechanisms behind iron transport and regulation, particularly in critical cellular structures like mitochondria. This work could lead to a deeper understanding of how metal imbalances contribute to diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to iron or copper metabolism, such as hemochromatosis or Wilson's disease.
Not a fit: Patients who do not have any metabolic disorders related to iron or copper may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing diseases related to iron and copper imbalances in the body.
How similar studies have performed: While the specific combination of techniques used in this research is novel, there have been successful studies exploring metal trafficking in cells, indicating potential for impactful findings.
Where this research is happening
COLLEGE STATION, UNITED STATES
- TEXAS A&M UNIVERSITY — COLLEGE STATION, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LINDAHL, PAUL A. — TEXAS A&M UNIVERSITY
- Study coordinator: LINDAHL, PAUL A.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cell injury, Cellular injury