Understanding how IRF4 affects the tumor environment in follicular lymphoma
Elucidating the role of IRF4 in reprogramming the tumor microenvironment in follicular lymphoma
This study is looking at how a protein called IRF4 affects the environment around tumors in people with follicular lymphoma, a type of blood cancer, to find new ways to improve treatment and help patients feel better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10806442 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called IRF4 in shaping the tumor microenvironment of follicular lymphoma, a type of blood cancer. By analyzing genetic and transcriptomic data, the study aims to uncover how IRF4 influences interactions between cancerous B cells and immune cells, which could lead to poor patient outcomes. The researchers will conduct experiments to explore how increased IRF4 expression alters immune responses and contributes to an immunosuppressive environment. This work seeks to identify potential therapeutic targets that could improve treatment strategies for patients with follicular lymphoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with follicular lymphoma, particularly those experiencing early relapse or poor prognosis.
Not a fit: Patients with other types of lymphoma or those who are not diagnosed with follicular lymphoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment approaches that enhance immune responses against follicular lymphoma.
How similar studies have performed: Previous research has shown promising results in understanding tumor-immune interactions in other cancers, suggesting that this approach may yield valuable insights for follicular lymphoma as well.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Mondello, Patrizia — Mayo Clinic Rochester
- Study coordinator: Mondello, Patrizia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.