Understanding how ion channels work using advanced infrared techniques
Official title: Data-driven modeling of the vibrational spectroscopy of ion channels
Funded at University of Delaware · NIH-11075367 · Data updated 2026-11-12
This study is looking at how tiny channels in our cells, which help move important ions, work and change when electricity flows through them, with the hope that understanding these processes better could lead to new treatments for heart-related issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Delaware NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | July 15, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $275,513 |
| NIH project number | 5R35GM150963-03 |
| Project ID | NIH-11075367 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are individuals with cardiovascular disorders, particularly those experiencing arrhythmias.
✕Less likely to help
Patients with non-cardiovascular conditions or those not affected by ion channel-related issues may not receive any benefit from this research.
What this research studies
This research focuses on developing new computational methods to simulate the vibrational spectroscopy of ion channels, which are crucial for transporting ions across cell membranes. By utilizing two-dimensional infrared (2D IR) spectroscopy, the research aims to investigate how these channels operate and respond to voltage changes. The goal is to gain insights into the mechanisms of ion transport and the molecular origins of selectivity in specific ion channels, which could lead to a better understanding of cardiovascular diseases. Patients may benefit from the findings as they could inform new treatments for conditions related to ion channel dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with cardiovascular diseases linked to ion channel dysfunction.
How similar studies have gone: While the use of 2D IR spectroscopy is an emerging technique, similar approaches in studying protein dynamics have shown promise, indicating potential for success in this novel application.
Where this research is happening
-
University of Delaware
Newark, United States Active
Researchers
- Principal investigator: Kananenka, Alexei — University of Delaware
- Study coordinator: Kananenka, Alexei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.