Understanding how ion channels and enzymes work in cell membranes
Mechanisms of Ion Channels and Enzymatic Membrane Proteins
This study is looking at how certain proteins in our cells help control the flow of ions and support energy production, which could lead to new treatments for conditions caused by problems with these proteins, especially for those who have issues with calcium regulation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11053553 on NIH RePORTER |
What this research studies
This research investigates the structural and functional mechanisms of ion channels and membrane enzymes in eukaryotic cells. By using advanced techniques like X-ray crystallography and cryo-electron microscopy, the team aims to uncover how these proteins conduct ions and catalyze reactions within lipid membranes. The study focuses on key proteins such as the mitochondrial calcium uniporter, which plays a crucial role in regulating calcium entry and ATP synthesis. Patients may benefit from insights gained into how these proteins function, potentially leading to new treatments for conditions related to ion channel dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with conditions related to ion channel dysfunction, such as certain types of cancer or metabolic disorders.
Not a fit: Patients with conditions unrelated to ion channel or membrane enzyme function may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases linked to ion channel and enzyme malfunctions.
How similar studies have performed: Previous research has shown success in understanding ion channels and membrane proteins, indicating that this approach is built on established scientific foundations.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Long, Stephen Barstow — Sloan-Kettering Inst Can Research
- Study coordinator: Long, Stephen Barstow
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.