Understanding how ion channels and calcium regulation affect heart disease
Official title: Systems Approach to Understanding Cardiovascular Disease - Ion channels, Ca2+ regulation and signaling
Funded at University of California at Davis · NIH-10996430 · Data updated 2026-11-12
This study is looking at how different cells in the heart work together and how that affects heart problems like high blood pressure and irregular heartbeats, with the goal of finding better treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $20,000 |
| NIH project number | 1R13HL175922-01 |
| Project ID | NIH-10996430 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from cardiovascular diseases such as hypertension, heart failure, or arrhythmias.
✕Less likely to help
Patients with non-cardiovascular conditions or those without any cardiovascular risk factors may not receive benefit from this research.
What this research studies
This research focuses on the mechanisms behind cardiovascular diseases, such as hypertension and arrhythmias, by integrating experimental data into mathematical models. By analyzing how different cells in the cardiovascular system interact, the research aims to uncover complex biological behaviors that contribute to heart dysfunction. Patients may benefit from improved therapies developed through a deeper understanding of these mechanisms. The approach combines experimental findings with computational tools to create a comprehensive view of cardiovascular health.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective therapies for cardiovascular diseases.
How similar studies have gone: Other research has shown success in using similar integrative approaches to understand complex biological systems, indicating potential for impactful findings in this area.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Grandi, Eleonora — University of California at Davis
- Study coordinator: Grandi, Eleonora
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.