Understanding how ion channels affect uterine contractions and reproductive health
Ion Channels Critical for Uterine Contraction, Reproduction, and Adenomyosis
This study is looking at how tiny channels in the muscle cells of the uterus work, which is important for things like your period and pregnancy, to better understand conditions like adenomyosis that can cause pain and trouble getting pregnant.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11134072 on NIH RePORTER |
What this research studies
This research investigates the role of ion channels in uterine smooth muscle cells, which are essential for processes like menstruation and embryo implantation. By examining how these channels function and their impact on uterine peristalsis, the study aims to uncover the molecular mechanisms behind conditions like adenomyosis, which can lead to infertility and significant distress for women. The researchers will utilize various experimental models, including genetically modified mice, to explore how disruptions in calcium signaling affect uterine function.
Who could benefit from this research
Good fit: Ideal candidates for this research include women experiencing adenomyosis, infertility, or other reproductive health challenges.
Not a fit: Patients who do not have adenomyosis or related reproductive disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for women suffering from adenomyosis and related reproductive issues.
How similar studies have performed: Previous research has shown promising results in understanding calcium signaling in uterine function, suggesting that this approach could yield valuable insights.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Zhuge, Ronghua — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Zhuge, Ronghua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.