Understanding how ion channels affect uterine contractions and reproductive health
Official title: Ion Channels Critical for Uterine Contraction, Reproduction, and Adenomyosis
Funded at Univ of Massachusetts Med Sch Worcester · NIH-11134072 · Data updated 2026-11-12
This study is looking at how tiny channels in the muscle cells of the uterus work, which is important for things like your period and pregnancy, to better understand conditions like adenomyosis that can cause pain and trouble getting pregnant.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | June 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $584,074 |
| NIH project number | 1R01HD114722-01A1 |
| Project ID | NIH-11134072 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include women experiencing adenomyosis, infertility, or other reproductive health challenges.
✕Less likely to help
Patients who do not have adenomyosis or related reproductive disorders may not benefit from this research.
What this research studies
This research investigates the role of ion channels in uterine smooth muscle cells, which are essential for processes like menstruation and embryo implantation. By examining how these channels function and their impact on uterine peristalsis, the study aims to uncover the molecular mechanisms behind conditions like adenomyosis, which can lead to infertility and significant distress for women. The researchers will utilize various experimental models, including genetically modified mice, to explore how disruptions in calcium signaling affect uterine function.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for women suffering from adenomyosis and related reproductive issues.
How similar studies have gone: Previous research has shown promising results in understanding calcium signaling in uterine function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Zhuge, Ronghua — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Zhuge, Ronghua
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.