Understanding how ion channels affect immune cell development and function
Official title: Ion channels regulating plasma cell differentiation and humoral immunity
Funded at New York University School of Medicine · NIH-11000839 · Data updated 2026-11-12
This study is looking at how certain tiny channels in our cells affect the growth and function of B cells, which are important for making antibodies to fight infections, and it aims to find new ways to help people with immune problems, like agammaglobulinemia, who struggle to produce enough antibodies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 13, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $648,546 |
| NIH project number | 5R01AI175276-02 |
| Project ID | NIH-11000839 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with primary immunodeficiencies, such as agammaglobulinemia or common variable immunodeficiency, as well as those with autoimmune conditions.
✕Less likely to help
Patients with fully functional immune systems or those not affected by B cell-related disorders may not benefit from this research.
What this research studies
This research investigates the role of ion channels in the development and function of B cells, which are essential for producing antibodies that protect against infections. The study focuses on how mutations in these ion channels can lead to immune deficiencies, such as agammaglobulinemia, where patients cannot produce adequate antibodies. By examining the mechanisms of B cell maturation and differentiation, the research aims to uncover potential therapeutic targets for improving immune responses in affected individuals. Patients may benefit from insights that could lead to new treatments for autoimmune diseases and immunodeficiencies.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance antibody production and improve immune responses in patients with immune deficiencies.
How similar studies have gone: Previous research has shown success in understanding the role of ion channels in immune cell function, indicating that this approach has potential for meaningful advancements.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Feske, Stefan — New York University School of Medicine
- Study coordinator: Feske, Stefan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.