Understanding how ion channels affect blood flow in the brain's small vessels
Ion Channel Dysfunction in Small Vessel Disease of the Brain
This study looks at how tiny channels in the brain's blood vessels help control blood flow to active brain cells, and it aims to find out how these processes change in small vessel disease, which could lead to better treatments for brain-related issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project ID | NIH-10596592 on NIH RePORTER |
What this research studies
This research investigates how ion channels in the brain's small blood vessels influence blood flow to active neurons. It focuses on the mechanisms of neurovascular coupling, which is the process that ensures adequate blood supply to neurons based on their activity. By studying the roles of specific ion channels and signaling pathways, the research aims to uncover how these processes are altered in small vessel disease, potentially leading to better understanding and treatment options for related brain disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with small vessel disease or related cerebrovascular conditions.
Not a fit: Patients with conditions unrelated to small vessel disease or those without any cerebrovascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for conditions related to impaired blood flow in the brain, improving outcomes for patients with small vessel disease.
How similar studies have performed: Other research has shown promising results in understanding neurovascular coupling and its implications for brain health, indicating that this approach has potential for success.
Where this research is happening
Burlington, United States
- University of Vermont & St Agric College — Burlington, United States (Active)
Researchers
- Principal investigator: Nelson, Mark T — University of Vermont & St Agric College
- Study coordinator: Nelson, Mark T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.